Monoclonal antibodies in cell‐mediated cytotoxicity against human melanoma and colorectal carcinoma

作者：Dorothee Herlyn, Meenhard Herlyn, Zenon Steplewski, Hilary Koprowski · 发表于：European Journal of Immunology · 年份：1979 · DOI：10.1002/eji.1830090817 · 被引用次数：147 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Viral Infectious Diseases and Gene Expression in Insects、Biosimilars and Bioanalytical Methods

Hybridoma-derived monoclonal anti-melanoma antibodies and anti-colorectal carcinoma antibodies were found to mediate in vitro antibody dependent cell-mediated cytotoxicity (ADCC) reactions against melanoma and colorectal carcinoma cells, respectively. The antigen(s) detected in ADCC on melanoma cells maintained for more than one hundred passages in tissue culture were also found on two recently established melanoma cell lines. These antigens were not detected on skin fibroblasts of the same patients from whom the melanomas were obtained. The ADCC reactivities of anti-melanoma and anti-colorectal carcinoma antibodies were found to be specific for melanoma cells and colorectal carcinoma cells, respectively.