New abietane diterpenoids from the cones of Larix kaempferi

作者：Hironori Ohtsu, Reiko Tanaka, Yasuko In, Shunyo Matsunaga, Harukuni Tokuda, Hoyoku Nishino · 发表于：Canadian Journal of Chemistry · 年份：2000 · DOI：10.1139/v99-218 · 被引用次数：29 · 研究领域：Biological Activity of Diterpenoids and Biflavonoids、Natural product bioactivities and synthesis、Phytochemistry and Biological Activities

A new podocarpane diterpene, 7α,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7α,13β,15,18-tetraol (2), 7α,13β,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13β,18-dihydroxyabiet-8(14)-en-7-one (4), 13β,15,18-trihydroxyabiet-8(14)-en-7-one (5), 7-oxo-13β-methoxyabiet-8(14)- en-18-oic acid (7), abiet-8(14)-en-7α,12α,13β,18-tetraol (8), 7α,12α,13β-trihydroxyabiet-8(14)-en-18-oic acid (9), and abiet-8(14)-en-7α,12α,13β,15,18-pentaol (10) were isolated from the CHCl3 extract of the cones of Larix kaempferi. Their structures were determined on the basis of chemical and spectral evidence. The inhibitory effects of compounds 1-4 and 7-9 on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), were examined for a primary screening for anti-tumor promotors. Key words: Larix kaempferi, Pinaceae, cones, abietane, EBV-EA.