Mutagenic Perylenequinone Metabolites of Alternaria alternata: Altertoxins I, II, and III

作者：Michael E Stack, Eugene P. Mazzola, Samuel W Page, Albert E Pohland, Robert J. Highet, Michael S. Tempesta, David G. Corley · 发表于：Journal of Natural Products · 年份：1986 · DOI：10.1021/np50047a017 · 被引用次数：94 · 研究领域：Fungal Plant Pathogen Control、Insect and Pesticide Research、Mycotoxins in Agriculture and Food

The mold genus Alternaria is a widely distributed plant pathogen. Some of these species, e.g., A. alternata, are common decay organisms of fruits and vegetables. Two novel perylene oxide metabolites, altertoxins II and III, have been identified in extracts of A. alternata isolates that exhibit mutagenic responses in the Ames Salmonella typhimurium assay. These identifications were based on mass, optical rotational, and 1H- and 13C-nmr spectral studies. Previous reports of related perylene dione mycotoxins have been clarified.