Valproic acid versus ethosuximide in the treatment of absence seizures

作者：Susumu Satô, BILLY G. WHITE, J. Kiffin Penry, Fritz E. Dreifuss, J. Chris Sackellares, Harvey J. Kupferberg · 发表于：Neurology · 年份：1982 · DOI：10.1212/wnl.32.2.157 · 被引用次数：200 · 研究领域：Epilepsy research and treatment、EEG and Brain-Computer Interfaces、Pharmacological Effects and Toxicity Studies

Valproic acid (VPA) and ethosuximide (ESM) were compared in a double-blind, response- conditional crossover study of absence seizures in 16 naive (previously untreated for absence seizures) and 29 refractory patients (18 male and 27 female; 4 to 18 years of age). In the naive patients VPA was as effective as ESM in reducing generalized spike-wave discharges on the telemetered EEG. Adverse reactions to VPA or ESM were generally mild and responded to withdrawal or dosage reduction of the drug.