Nerve Growth Factor: Stimulation of Regenerative Growth of Central Noradrenergic Neurons

作者：Anders Björklund, Ulf Stenevi · 发表于：Science · 年份：1972 · DOI：10.1126/science.175.4027.1251 · 被引用次数：155 · 研究领域：Biochemical effects in animals

The growth of new axonal sprouts was studied from transected, ascending noradrenergic axons into transplants of iris tissue in the caudal hypothalamus of the rat. A single intraventricular injection of nerve growth factor, given at the time of axonal damage, resulted in an increased formation and growth of new noradrenaline sprouts 7 days later. The effect seemed to be proportional to the administered dose of nerve growth factor.