Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.

作者：N Patronas, Giovanni Di Chiro, Rodney A. Brooks, Robert L. DeLaPaz, Paul L. Kornblith, Blair Hamilton Smith, Hugo V. Rizzoli, R M Kessler, Ronald G. Manning, Michael Almy Channing, Alfred P. Wolf, Christopher M. O’Connor · 发表于：Radiology · 年份：1982 · DOI：10.1148/radiology.144.4.6981123 · 被引用次数：301 · 研究领域：Brain Metastases and Treatment、Medical Imaging Techniques and Applications、Glioma Diagnosis and Treatment

Five patients who had undergone radiation therapy for cerebral tumors and whose conditions were deteriorating were examined by means of positron emission tomography (PET) with [18F] fluorodeoxyglucose. All five cases had similar clinical and computed tomographic findings. Using the PET technique the two cases of radiation necrosis were distinguished from the three recurrent tumors. In the two cases of radiation necrosis the rate of glucose utilization in the lesion was markedly reduced compared with the normal brain parenchyma. In the recurrent gliomas, however, the glucose metabolic rate was elevated. All five diagnoses were confirmed by biopsy or autopsy.