Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

作者：Angela I. M. Barth, Inke S Näthke, William James Nelson · 发表于：Current Opinion in Cell Biology · 年份：1997 · DOI：10.1016/s0955-0674(97)80122-6 · 被引用次数：540 · 研究领域：Wnt/β-catenin signaling in development and cancer、Cancer-related gene regulation、Kruppel-like factors research

Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.