Corticotropin-Releasing Activity of Monokines

作者：Barry M.R.N.J. Woloski, Eric Michael Smith, Walter J. Meyer, Gerald M. Fuller, James Edwin Blalock · 发表于：Science · 年份：1985 · DOI：10.1126/science.2997929 · 被引用次数：494 · 研究领域：Stress Responses and Cortisol、Adrenal Hormones and Disorders、Neuroendocrine regulation and behavior

Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin-releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.