Cryptococcal Disease in Patients with the Acquired Immunodeficiency Syndrome

作者：ABIGAIL ZUGER, Eddie Louie, Robert S. Holzman, Michael S. Simberkoff, James J. Rahal · 发表于：Annals of Internal Medicine · 年份：1986 · DOI：10.7326/0003-4819-104-2-234 · 被引用次数：526 · 研究领域：Fungal Infections and Studies、Nail Diseases and Treatments、Insects and Parasite Interactions

Between 1 January 1981 and 1 December 1984, 34 of 396 patients with the acquired immunodeficiency syndrome (AIDS) developed cryptococcal infections. Twenty-six cases are reviewed. Twenty-two patients had brain or meningeal disease; the others had pulmonary disease (2 patients), pericarditis (1 patient), and antigenemia (1 patient). During treatment, 3 patients died of cryptococcosis and 3 died of other causes. Fifteen patients were followed for more than 6 weeks after treatment. Of 8 patients who received no additional amphotericin B, 4 had relapses and died of cryptococcosis within 6 months, 3 died of other causes, and 1 survived. Of 7 patients who received maintenance therapy with amphotericin B, none had relapses, 3 died of other causes, and 4 survived. Our data suggest that maintenance therapy with amphotericin may be needed to prevent relapse in patients with AIDS.