A corticosteroid Receptor in Neuronal Membranes

作者：Miles Orchinik, Thomas F. Murray, Frank L. Moore · 发表于：Science · 年份：1991 · DOI：10.1126/science.2063198 · 被引用次数：524 · 研究领域：Receptor Mechanisms and Signaling、Stress Responses and Cortisol、Neuroendocrine regulation and behavior

Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.