Dementia, parkinsonism, and motor neuron disease: Neurochemical and neuropathological correlates

作者：J. J. Gilbert, Stephen J. Kish, Li‐Jan Chang, Caryl L. H. Morito, Kathleen S. Shannak, Oleh Hornykiewicz · 发表于：Annals of Neurology · 年份：1988 · DOI：10.1002/ana.410240518 · 被引用次数：37 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Cholinesterase and Neurodegenerative Diseases、Neuroscience and Neuropharmacology Research

The neurochemical markers for the major neurotransmitter systems were measured in the brain of a patient who died with a dementia-parkinsonism-motor neuron disease (DPMN) syndrome complex. Moderate neuronal loss in the substantia nigra, spongiform changes in the frontal cortex, and moderate anterior horn cell loss throughout the spinal cord were observed. A severe nigrostriatal dopamine deficiency provides the basis for the observed parkinsonian features. The dementia is unexplained.