Chronic Obstructive Pulmonary Disease Stage and Health-Related Quality of Life

作者：Montserrat Ferrer, Jordi Alonso, Josep Morera, Ramon M. Marrades, Ahmad Khalaf, M. Carmen Aguar, Vicente Plaza, Luis Prieto, Josep M. Anto · 发表于：Annals of Internal Medicine · 年份：1997 · DOI：10.7326/0003-4819-127-12-199712150-00003 · 被引用次数：433 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Chronic Disease Management Strategies

BACKGROUND: The American Thoracic Society recently recommended that chronic obstructive pulmonary disease be staged on the basis of the percentage of predicted FEV1. OBJECTIVE: To examine 1) the relation between the american Thoracic Society system for staging chronic obstructive pulmonary disease and health-related quality of life and 2) the effect of self-reported comorbid conditions on health-related quality of life. DESIGN: Cross-sectional study. SETTING: Outpatient clinics of respiratory departments of four hospitals and one primary health care center in spain. PATIENTS: 321 consecutive male patients with chronic obstructive pulmonary disease. MEASUREMENTS: Functional respiratory impairment, FEV1, respiratory symptoms, and health-related quality of life. Respiratory symptoms and health-related quality of life were measured by using the Spanish version of the St. George's Respiratory Questionnaire and the Nottingham Health Profile. RESULTS: Patient scores on the St. George's Respiratory Questionnaire were moderately to strongly associated with disease staging (r = 0.27 to 0.51). Compared with reference values, values for health-related quality of life for patients with stage I disease were substantially higher on the St. George's Respiratory Questionnaire (6 and 34; p < 0.001) and values for impairment were significantly greater in stage 1 patients with comorbid conditions (19 and 36; P = 0.001). At least one concomitant chronic condition was found in 84% of study patient...