Key role of lipids in heat stress management

作者：Gábor Balogh, Mária Péter, Attila Glatz, Imre Gombos, Zsolt Török, Ibolya Horváth, John L. Harwood, László Vı́gh · 发表于：FEBS Letters · 年份：2013 · DOI：10.1016/j.febslet.2013.05.016 · 被引用次数：192 · 研究领域：Adipose Tissue and Metabolism、Lipid metabolism and biosynthesis、Neurobiology and Insect Physiology Research

Heat stress is a common and, therefore, an important environmental impact on cells and organisms. While much attention has been paid to severe heat stress, moderate temperature elevations are also important. Here we discuss temperature sensing and how responses to heat stress are not necessarily dependent on denatured proteins. Indeed, it is clear that membrane lipids have a pivotal function. Details of membrane lipid changes and the associated production of signalling metabolites are described and suggestions made as to how the interconnected signalling network could be modified for helpful intervention in disease.