Extracellular Potassium Accumulation and Inward-Going Potassium Rectification in Voltage Clamped Ventricular Muscle

作者：Lars Nilausen Cleemann, Martin Morad · 发表于：Science · 年份：1976 · DOI：10.1126/science.1246599 · 被引用次数：31 · 研究领域：Neuroscience and Neural Engineering、Ion channel regulation and function、Cardiac electrophysiology and arrhythmias

Measurements of afterpotential, action potential duration, and output of a potassium-sensitive microelectrode indicate that the application of long clamp pulses (1 to 8 seconds) to frog ventricular muscle is accompanied by a change in the extracellular potassium concentration. The plot of the magnitude of the potassium accumulation against the clamped membrane potential yields an N-shaped relation similar to the "steady state" current-voltage relation. The accumulation studies confirm a strong inward-going (anomalous) potassium rectification.