The 5-D itch scale: a new measure of pruritus

作者：Scott Andrew Elman, Linda Susan Hynan, Vincent Gabriel, Marlyn J. Mayo · 发表于：British Journal of Dermatology · 年份：2009 · DOI：10.1111/j.1365-2133.2009.09586.x · 被引用次数：544 · 研究领域：Dermatology and Skin Diseases、Burn Injury Management and Outcomes、Wound Healing and Treatments

BACKGROUND: Itching is a subjective and multidimensional experience which is difficult to quantify. Most methodologies to assess itching suffer from being unidimensional, for example only measuring intensity without impact on quality of life, or only measuring scratching activity. None has actually been demonstrated to be able to detect change over time, which is essential to using them as an outcome measure of response to an intervention. The 5-D itch scale was developed as a brief but multidimensional questionnaire designed to be useful as an outcome measure in clinical trials. The five dimensions are degree, duration, direction, disability and distribution. OBJECTIVES: To study the 5-D with respect to validity, reliability and response to change. METHODS: The 5-D was administered to 234 individuals with chronic pruritus due to liver disease (n = 63), kidney disease (n = 36), dermatological disorders (n = 56), HIV/AIDS (n = 28) and burn injuries (n = 51). The 5-D was administered at baseline and after a 6-week follow-up period. A subset of 50 untreated patients was retested after 3 days to assess test-retest reliability. RESULTS: The 5-D score correlated strongly with a visual analogue score: r = 0.727 at baseline (P < 0.0001), r = 0.868 at the 3-day repeat (P < 0.0001), and r = 0.892 at the 6-week follow-up (P < 0.0001). There was no change in mean 5-D score between day 1 and day 3 in untreated individuals (intraclass correlation coefficient = 0.96, P < 0.0001). The 5-D di...