Mitochondrial Dysfunction and Type 2 Diabetes

作者：Bradford B. Lowell, Gerald I. Shulman · 发表于：Science · 年份：2005 · DOI：10.1126/science.1104343 · 被引用次数：2069 · 研究领域：Adipose Tissue and Metabolism、Pancreatic function and diabetes、Liver Disease Diagnosis and Treatment

Maintenance of normal blood glucose levels depends on a complex interplay between the insulin responsiveness of skeletal muscle and liver and glucose-stimulated insulin secretion by pancreatic beta cells. Defects in the former are responsible for insulin resistance, and defects in the latter are responsible for progression to hyperglycemia. Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction.