Selenium: Biochemical Role as a Component of Glutathione Peroxidase

作者：John T. Rotruck, Alun Lloyd Pope, Howard E. Ganther, Anne Barrett Swanson, Dean G. Hafeman, William G. Hoekstra · 发表于：Science · 年份：1973 · DOI：10.1126/science.179.4073.588 · 被引用次数：7832 · 研究领域：Selenium in Biological Systems、Heavy Metal Exposure and Toxicity、Trace Elements in Health

When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the (75)Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.