DNA Binding by Proteins

作者：Robert Schleif · 发表于：Science · 年份：1988 · DOI：10.1126/science.2842864 · 被引用次数：198 · 研究领域：DNA and Nucleic Acid Chemistry、RNA and protein synthesis mechanisms、Genomics and Chromatin Dynamics

Study of proteins that recognize specific DNA sequences has yielded much information, but the field is still in its infancy. Already two major structural motifs have been discovered, the helix-turn-helix and zinc finger, and numerous examples of DNA-binding proteins containing either of them are known. The restriction enzyme Eco RI uses yet a different motif. Additional motifs are likely to be found as well. There is a growing understanding of some of the physical chemistry involved in protein-DNA binding, but much remains to be learned before it becomes possible to engineer a protein that binds to a specific DNA sequence.