Atypical presentation of progressive supranuclear palsy

作者：Patricia H. Davis, Christine S. Bergeron, Donald R. Crapper McLachlan · 发表于：Annals of Neurology · 年份：1985 · DOI：10.1002/ana.410170406 · 被引用次数：240 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Botulinum Toxin and Related Neurological Disorders、Neurological diseases and metabolism

Four pathologically documented cases of progressive supranuclear palsy are reported. Two patients exhibited severe dementia and 2 parkinsonism; none had the classic ophthalmoplegia. On retrospective analysis, clues to the diagnosis included early prominent gait disturbance, apraxia of eyelid opening in 1 patient, lack of tremor, poor response to levodopa-carbidopa, and severe rigidity with a posture of neck extension terminally in 1 patient. The clinical presentation of progressive supranuclear palsy, therefore, is not as stereotyped as previously thought, and the diagnosis can be overlooked if one adheres rigidly to the classic diagnostic criteria.