Asymmetric Synthesis of Salvinorin A, A Potent κ Opioid Receptor Agonist

作者：Jonathan R. Scheerer, Jonathan F. Lawrence, Grace C. Wang, David Albert Evans · 发表于：Journal of the American Chemical Society · 年份：2007 · DOI：10.1021/ja073590a · 被引用次数：163 · 研究领域：Neuropeptides and Animal Physiology、Alkaloids: synthesis and pharmacology、Chemical synthesis and alkaloids

The stereoselective synthesis of salvinorin A is described. A macrocyclic bis-Michael reaction cascade provides the requisite tricyclic skeleton as a single diastereomer.