Increased Cytokines Response in Patients with Tuberculosis Complicated with Chronic Obstructive Pulmonary Disease

作者：Shenjie Tang, Haiyan Cui, Lan Yao, Xiaohui Hao, Yun Shen, Lin Fan, Hua Sun, Zhanjun Zhang, Jian Huang · 发表于：PLoS ONE · 年份：2013 · DOI：10.1371/journal.pone.0062385 · 被引用次数：39 · 研究领域：Tuberculosis Research and Epidemiology、Chronic Obstructive Pulmonary Disease (COPD) Research、Philosophy, Health, and Society

OBJECTIVES: To explore the change and its significance of cytokines in patients with pulmonary tuberculosis complicated with COPD. METHODS: The immune function of 152 cases of pulmonary tuberculosis with COPD was detected to compare with 150 cases of patients with pulmonary tuberculosis, 157 cases of patients with COPD and 50 cases of healthy volunteers who were in the hospital during the same period. T lymphocyte cell population in peripheral blood was detected by flow cytometry. The serum levels of sIL-2R, IL-6, IFN-γ, TNF-α were measured using ELISA. RESULTS: The percentage of CD4+ T cells in TB patients with or without COPD and COPD patients without TB was significantly lower than that in control group. The percentage of CD4+ T cells in patients with TB and COPD was significantly lower than that in the non-COPD TB patients. The percentage of CD8+ T cells was higher in the TB patients group than that in control group. The CD4+/CD8+ ratio in the TB patients group was significantly lower than that in control group. The concentrations of sIL-2R, IL-6, TNF-α, IFN-γ in TB patients with or without COPD and COPD patients without TB were significantly higher than those in control group. In addition, sIL-2R, IL-6, TNF-α concentrations in the patients with TB and COPD were higher than those in the non-COPD TB patients. The concentrations of sIL-2R, IL-6, TNF-α, IFN-γ in COPD patients with TB were significantly higher than those in COPD patients without TB. There was a significant ne...