The genome of the model beetle and pest Tribolium castaneum

作者：Stephen Richards, Richard A. Gibbs, George M. Weinstock, Richard Gibbs, Muzny Dm, Tony Attaway, Stephanie Bell, Christian Buhay, Mimi N. Chandrabose, Dean Chavez, Kerstin P. Clerk-Blankenburg, Andrew Cree, Marvin Dao, Clay Davis, Chacko Jg, Huyen Dinh, Shannon Dugan-Rocha, Gerald Fowler, Toni T. Garner, A C Hawes, Judith Hernandez, Sandra Hines, Michael Holder, Jennifer Hume, Shalini N. Jhangiani, Vandita Joshi, Ziad Khan, LaRonda Jackson, Christie Kovar, Andrea Kowis, Sandra Lee, Lora R. Lewis, Margaret Morgan, Lynne V. Nazareth, N Thao T Nguyen, Geoffrey Okwuonu, David L. Parker, San-Juana Ruiz, Jireh Santibanez, Steven E. Scherer, Brian Schneider, Erica Sodergren, Selina Vattahil, Donna Villasana, Courtney White, Rita Wright, George M. Weinstock, Yue Liu, Kim Worley, Henry Song, Lan Zhang, Susan J. Brown, Robin E. Denell, Marce Lorenzen, Susan Brown, Liangjiang Wang, Suzhi Wang, Renata Bolognesi, Robin E. Denell, Cassondra M. Gordon, Teresa D. Shippy, Yoshinori Tomoyasu, Jeremy Marshall, Sherry Miller, Richard W. Beeman, Jeff Lord, Brenda Oppert, Karl J. Kramer, Yasuyuki Arakane, Cris Oppert, Gregor Bucher, Nico Posnien, Johannes B. Schinko, Franck Simonnet, Ernst A. Wimmer, Stefan Schuetz, Daniela Großmann, Markus Friedrich, Riyue Bao, Xiaoyun Yang, Cornelis J.P. Grimmelikhuijzen, Frank Hauser, Giuseppe Cazzamali, Michael Williamson, Martin Klingler, C. Schmitt, Michael Schoppmeier, Jochen Trauner, Siegfried Roth, Cornelia Von Levetsow, Jeremy Lynch, Rodrigo Nunes da Fonseca, Reinhard Schröder, Anke Beermann, Nicola Berns, Rebekka Lutz, Rolf Reuter, Nadine Wittkopp, Diethard Tautz, Joël Savard, Manuel Aranda, Henrique Marques‐Souza, Maurijn van der Zee, Evgeny M. Zdobnov, Stefan Wyder, Evgenia V. Kriventseva, Robert M. Waterhouse, Jeffrey Garnes, Andreas Gnirke, Jon Margolis, Yoonseong Park, Bin Li, Christine G. Elsik, Justin T. Reese, Eran Elhaik, Giddy Landan, Dan Graur, Peter Arensburger, Peter Atkinson, Beidler Jg, Zhijian Tu, Jeffery P. Demuth, Douglas W. Drury, Du Y, Jianjun Wang, Haruhiko Fujiwara, Mizuko Osanai, Vincenza Maselli, Hugh M. Robertson, Kimberly K. O. Walden, Doreen Werner, Mario Stanke, Burkhard Morgenstern, Victor Solovyev, Peter Kosarev, Garth Brown, Hsiu-Chuan Chen, Olga Ermolaeva, Wratko Hlavina, Yuri Kapustin, Boris Kiryutin, Paul Kitts, D R Maglott, Pruitt Km, Victor Sapojnikov, Alexandre Souvorov, Aaron J. Mackey, Tatsuhiko Kadowaki, P BORK, Florian Raible, François Bonneton, Laudet, Daniel Bopp, Butts Tm, David Ferrier, Arnaud Chaumot, Marek Jindra, Que Lan, H. Michael G. Lattorff, Zhenyi Liu, Michel Vervoort, Andrew K. Jones, D. B. Sattelle, Paul R. Ebert, David Nelson, Jeffrey G. Scott, S Muthukrishnan, Qingsong Zhu, David Hogenkamp, R Dixit, Haobo Jiang, Zhen Zou, Zhiqiang Lu, Picheng Zhao, Niranji Sumathipala, Elena Elpidina, Vinokurov Ks, Jay Evans, Boran Altincicek, Andreas Vilcinskas, Michael Williams, Dan Hultmark, C Hetru, Yoshiaki Tanaka, Reinhard Predel, Susanne Neupert, Joachim Schachtner, Peter Verleyen, Sergio Angeli, Sylvain Forêt, Ryszard Maleszka · 发表于：Nature · 年份：2008 · DOI：10.1038/nature06784 · 被引用次数：1437 · 研究领域：Insect Resistance and Genetics、Forest Insect Ecology and Management、Insect-Plant Interactions and Control

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell–cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control. The red flour beetle Tribolium castaneum is a common pest: a type of 'bran bug', it targets cereal products, including grain, flour and rice bran. It is also a commonly used laboratory model, combining the ease of systematic RNA interference experiments such as those used with the nematode worm C. elegans with a biology that is more representative of most insects than even Drosophila. This weeks sees the publication by the Tribolium Genome Sequencing Consortium of the...