The International HapMap Project

作者：Richard A. Gibbs, John W. Belmont, Paul Hardenbol, T. D. Willis, Fuli Yu, Huanming Yang, Lan-Yang Ch'ang, Wei Huang, Bin Liu, Yan Shen, Paul Kwong Hang Tam, Lap-Chee Tsui, Mary Miu Yee Waye, J. Tze‐Fei Wong, Changqing Zeng, Qingrun Zhang, Illumina, Mark S. Chee, Luana Galver, Semyon Kruglyak, Sarah Shaw Murray, Arnold Oliphant, Alexandre Montpetit, Thomas Jay Hudson, Fanny Chagnon, Vincent Ferretti, Martin Leboeuf, Michael Phillips, Andrei Verner, Pui-Yan Kwok, Shenghui Duan, Denise L. Lind, Raymond D. Miller, John P. Rice, Nancy L. Saccone, Patricia Taillon‐Miller, Ming Xiao, Yusuke Nakamura, Akihiro Sekine, Koki Sorimachi, Toshihiro Tanaka, Yoïchi Tanaka, Tatsuhiko Tsunoda, Eiji Yoshino, David Bentley, Panos Deloukas, Sarah E Hunt, Don Powell, David Altshuler, Stacey B. Gabriel, Houcan Zhang, Changqing Zeng, Ichiro Matsuda, Yoshimitsu Fukushima, Darryl R J Macer, Eiko Suda, Charles N. Rotimi, Clement Adebamowo, Toyin I.G. Aniagwu, Patricia A. Marshall, Olayemi Matthew, Chibuzor Nkwodimmah, Charmaine D. M. Royal, Mark Leppert, Missy Dixon, Lincoln D. Stein, Fiona M Cunningham, Ardavan Kanani, Guðmundur Á. Þórisson, Aravinda Chakravarti, Peter E. Chen, David J. Cutler, Carl Kashuk, Peter Donnelly, Jonathan Marchini, Gil McVean, Simon Robert Myers, Lon R. Cardon, Gonçalo R. Abecasis, Andrew Paul Morris, Bruce S. Weir, James C. Mullikin, Stephen T. Sherry, Michael Feolo, David Altshuler, Mark Daly, Stephen F. Schaffner, Ren-Zong Qiu, Genetic Interest Group, Alastair Kent, Georgia M. Dunston, Kazuto Kato, Norio Niikawa, Bartha Maria Knoppers, Morris W. Foster, Ellen Wright Clayton, Vivian Ota Wang, Wellcome Trust, Jessica Watkin, Richard A. Gibbs, John W. Belmont, Erica J Sodergren, George M. Weinstock, Richard K. Wilson, Lucinda Fulton, Jane Rogers, Susan J. Birren, Hua Han, Chinese Ministry of Science and Technology, Hongguang Wang, Genome Canada, Martin Godbout, John C. Wallenburg, Génome Québec, Paul L'Archevêque, Guy Bellemare, Japanese Ministry of Education, Culture, Sports, Science and Technology, Kazuo Todani, Takashi Fujita, Satoshi Tanaka, Arthur L. Holden, Eric Lai, Francis S. Collins, Lisa D. Brooks, Jean E. McEwen, Mark S. Guyer, Elke Jordan, Jane L. Peterson, Jack Spiegel, Lawrence M. Sung, Lynn F. Zacharia, Wellcome Trust, Karen Kennedy, Michael G. Dunn, Richard Seabrook, Mark Shillito, Barbara Skene, John G. Stewart, Initial Planning Groups: Populations and Ethical, Legal and Social Issues Group, David Valle, Ellen Wright Clayton, Lynn B. Jorde, John W. Belmont, Aravinda Chakravarti, Mildred K. Cho, Troy Duster, Morris W. Foster, Marla Jasperse, Bartha Maria Knoppers, Pui-Yan Kwok, Júlio Licinio, Jeffrey C. Long, Patricia A. Marshall, Pilar N. Ossorio, Vivian Ota Wang, Charles N. Rotimi, Charmaine D. M. Royal, Patricia Spallone, Sharon F. Terry, Methods Group, Eric S. Lander, Eric Lai, Deborah A. Nickerson, Gonçalo R. Abecasis, David Altshuler, David Bentley, Michael Boehnke, Lon R. Cardon, Mark Daly, Panos Deloukas, Julie A. Douglas, Stacey B. Gabriel, Richard R. Hudson, Thomas Jay Hudson, Leonid Kruglyak, Pui-Yan Kwok, Yusuke Nakamura, Robert L. Nussbaum, Charmaine D. M. Royal, Stephen F. Schaffner, Stephen T. Sherry, Lincoln D. Stein, Toshihiro Tanaka · 发表于：Nature · 年份：2003 · DOI：10.1038/nature02168 · 被引用次数：6187 · 研究领域：Genomics and Rare Diseases、Genomic variations and chromosomal abnormalities、Genetic Associations and Epidemiology

The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.