Further studies on the therapeutic effect of indomethacin on esophageal tumors

作者：Carlos Rubio‐Terres · 发表于：Cancer · 年份：1986 · DOI：10.1002/1097-0142(19860901)58:5<1029::aid-cncr2820580508>3.0.co;2-d · 被引用次数：69 · 研究领域：Inflammatory mediators and NSAID effects、Helicobacter pylori-related gastroenterology studies、Cancer, Stress, Anesthesia, and Immune Response

The effect of treatment with the nonsteroid anti-inflammatory drug indomethacin, was investigated in 250 3-month-old C57Bl female mice following induction of esophageal tumors with diethylnitrosamine (DEN). Already 3 months after DEN treatment, many esophageal tumors were committed to occur: despite discontinued DEN treatment, the number of tumors had increased significantly at 6 or 9 months of observation. Following 3 and 4 months of DEN administration, the development of many already committed esophageal tumors was significantly abrogated by treating the mice with indomethacin.