Tumor Promoters Inhibit Morphological Differentiation in Cultured Mouse Neuroblastoma Cells

作者：Douglas N. Ishii, Eitan Fibach, Hiroshi Yamasaki, I. Bernard Weinstein · 发表于：Science · 年份：1978 · DOI：10.1126/science.644318 · 被引用次数：129 · 研究领域：Bioactive Natural Diterpenoids Research、Sesquiterpenes and Asteraceae Studies、Biological Activity of Diterpenoids and Biflavonoids

When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.