Red blood cell transfusion and ventilator-associated pneumonia: A potential link?

作者：Andrew F. Shorr, Mei Sheng Duh, KATHLEEN M. KELLY, Marin H. Kollef · 发表于：Critical Care Medicine · 年份：2004 · DOI：10.1097/01.ccm.0000114810.30477.c3 · 被引用次数：211 · 研究领域：Blood transfusion and management、Nosocomial Infections in ICU、Trauma, Hemostasis, Coagulopathy, Resuscitation

OBJECTIVE: To determine the relationship between packed red blood cell transfusion practice and the development of ventilator-associated pneumonia (VAP). DESIGN: Secondary analysis of a multicentered, prospective observational study of transfusion practice in intensive care units in the United States. SETTING: A total of 284 intensive care units in the United States were studied from August 2000 to April 2001. PATIENTS: Patients without pneumonia at intensive care unit admission and who then required at least 48 hrs of mechanical ventilation were considered at risk for VAP. MEASUREMENTS AND MAIN RESULTS: VAP was diagnosed based on prospectively defined clinical criteria and represented the primary study end point. Late-onset VAP (VAP arising after > or =5 days of mechanical ventilation) represented a secondary end point. Transfusions given during the intensive care unit stay and before the onset of VAP were tracked prospectively. Of 4,892 subjects in the original cohort, 1,518 received mechanical ventilation of > or =48 hrs and did not have preexisting pneumonia. VAP was diagnosed in 311 (20.5%) patients. Multivariate analysis revealed that transfusion independently increased the risk for VAP (odds ratio, 1.89; 95% confidence interval [CI], 1.33-2.68). Other factors increasing the risk for VAP included male sex (odds ratio, 1.54; 95% CI, 1.15-2.07), admission after trauma (odds ratio, 1.68; 95% CI, 1.15-2.47), use of continuous sedation (odds ratio, 1.43; 95% CI, 1.07-1.92), ...