Myoclonus During Prolonged Treatment with Sertraline in an Adolescent Patient

作者：Neera Ghaziuddin, Anjum Iqbal, Seloni Khetarpal · 发表于：Journal of Child and Adolescent Psychopharmacology · 年份：2001 · DOI：10.1089/104454601750284126 · 被引用次数：15 · 研究领域：Glycogen Storage Diseases and Myoclonus、Neurological disorders and treatments、Autoimmune Neurological Disorders and Treatments

A 15-year-old female adolescent with depression developed myoclonus after uninterrupted treatment with sertraline over 6 years. She was also receiving methylphenidate. Withdrawal of sertraline and continuation of methylphenidate did not result in any improvement. Treatment with valproic acid resulted in improvement of the movement disorder. This report suggests that myoclonus may be a side effect of sertraline in some adolescents. Further, we hypothesized that extended treatment over several years, young age, and a compromised central nervous system due to underlying disorders may be risk factors for the development of this side effect.