Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

作者：Koichi Ishiguro, Shunsuke Kobayashi, Akira Onion, Masako Takamatsu, S. Yonekura, Kaijiro Anzai, Kazutomo Imahori, Tsuneko Uchida · 发表于：FEBS Letters · 年份：1994 · DOI：10.1016/0014-5793(94)80501-6 · 被引用次数：147 · 研究领域：Alzheimer's disease research and treatments、Cancer-related Molecular Pathways、Microtubule and mitosis dynamics

Tau protein kinase II (TPKII) was reported previously to be composed of a neuron-rich cdc2-related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2-related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.