Complete coding sequence of rat tyrosine hydroxylase mRNA.

作者：Brigitte Grima, A. Lamouroux, F. Blanot, Nicole Faucon Biguet, Jacques Mallet · 发表于：Proceedings of the National Academy of Sciences · 年份：1985 · DOI：10.1073/pnas.82.2.617 · 被引用次数：539 · 研究领域：Metabolism and Genetic Disorders、Amino Acid Enzymes and Metabolism、Enzyme Structure and Function

Several clones specific for tyrosine hydroxylase [tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] have been identified from a rat PC12 library by using the previously characterized clone pTH-1. The most complete of these, pTH-51, is 1758 base pairs long and covers most of the length of the mRNA, including the entire coding and 3' untranslated region. The polypeptide has an estimated molecular weight of 55,903 and some of its characteristic features are discussed.