Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

作者：Charles Edward Hart, John W. Forstrom, James D. Kelly, Ronald A. Seifert, Robert Anthony Smith, Russell Ross, Mark J. Murray, Daniel F. Bowen‐Pope · 发表于：Science · 年份：1988 · DOI：10.1126/science.2836952 · 被引用次数：588 · 研究领域：Eosinophilic Disorders and Syndromes、Platelet Disorders and Treatments、Cell Adhesion Molecules Research

Previous studies involving platelet-derived growth factor (PDGF) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB, and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptor as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.