Toxic Shock Syndrome and Lysogeny in Staphylococcus aureus

作者：Steven E. Schutzer, Vincent A. Fischetti, John B. Zabriskie · 发表于：Science · 年份：1983 · DOI：10.1126/science.6220467 · 被引用次数：39 · 研究领域：Bacteriophages and microbial interactions、Bacillus and Francisella bacterial research、Bacterial Genetics and Biotechnology

Lysogeny, or the presence of temperate bacteriophage, was demonstrated, by means of two Staphylococcus aureus indicator strains, in 11 of 12 strains of S. aureus isolated from patients with toxic shock syndrome. Only 1 of 18 strains of S. aureus that were not associated with toxic shock syndrome showed the presence of bacteriophage. A laboratory strain of S. aureus was lysogenized by bacteriophage from two of the toxic shock-associated strains. These results add support to the theory that lysogeny by one or more bacteriophage in certain strains of S. aureus may be responsible for the pathogenesis of toxic shock syndrome.