Ciprofloxacin treatment of periapical Pseudomonas aeruginosa infection

作者：Frederic Barnett, Peter Axelrod, Leif Tronstad, Jørgen Slots, Amy L. Graziani, George H. Talbot · 发表于：Dental Traumatology · 年份：1988 · DOI：10.1111/j.1600-9657.1988.tb00311.x · 被引用次数：21 · 研究领域：Endodontics and Root Canal Treatments、Orthopedic Infections and Treatments、Infectious Diseases and Tuberculosis

Abstract Survival of bacteria in periapical tissues may be the reason for endodontic failures. This case report describes the treatment of a patient with periapical lesions refractory to endodontic treatment. Microbiological sampling from fistulae associated with the lesions revealed the presence of Pseudomonas aeruginosa. Phenoxymethyl penicillin, metronidazole and carbenicillin were ineffective in eliminating the periapical infection. However, an investigational antibiotic, Ciprofloxacin, which was administered orally twice daily for 15 weeks, proved to be an effective, safe and convenient medicament in the treatment of periapical Pseudomonas aeruginosa infection. The fistulae closed in less than 2 weeks and a radiograph taken during the fourteenth week of therapy showed healing of the apical periodontitis with osseous regeneration. It is suggested that Ciprofloxacin is a valuable agent in the treatment of apical periodontitis, and probably other odontogenic infections caused by susceptible aerobic gram‐negative bacilli.