Connective tissue synthesis by cultured scleroderma fibroblasts. I. In vitro collagen synthesis by normal and scleroderma dermal fibroblasts

作者：Jerome S. Perlish, Reza I. Bashey, Ralph E. Stephens, Raúl Fleischmajer · 发表于：Arthritis & Rheumatism · 年份：1976 · DOI：10.1002/art.1780190510 · 被引用次数：75 · 研究领域：Skin and Cellular Biology Research、Systemic Sclerosis and Related Diseases、Dermatologic Treatments and Research

The authors have been unable to demonstrate an increase in collagen synthesis by fibroblasts isolated from sclerodermatous skin. In order to elucidate this problem further, scleroderma fibroblasts were biopsied from upper dermis, from lower (including subcutaneous) dermis, and from adjacent clinically noninvolved skin. All cell lines failed to show a significant increase in collagen synthesis when they were compared to control fibroblast lines. One difference among them was that fibroblasts from involved areas showed a rate of collagen synthesis equal to or less than cells isolated from adjacent clinically noninvolved sites.