The Burden of Gastrointestinal and Liver Diseases, 2006

作者：Nicholas J. Shaheen, Richard A. Hansen, Douglas R. Morgan, Lisa M. Gangarosa, Yehuda Ringel, Michelle T. Thiny, Mark W. Russo, Robert S. Sandler · 发表于：The American Journal of Gastroenterology · 年份：2006 · DOI：10.1111/j.1572-0241.2006.00723.x · 被引用次数：705 · 研究领域：Drug-Induced Hepatotoxicity and Protection、Liver Disease Diagnosis and Treatment、Liver Diseases and Immunity

BACKGROUND: Digestive and liver diseases are a source of significant morbidity, mortality, and health-care costs for the U.S. population. An annual report of the toll of these diseases could be helpful to clinicians, policymakers, and researchers. AIM: To describe the epidemiology of gastrointestinal and liver diseases in the United States using data from privately and publicly held databases. METHODS: We collected data from the National Center for Health Statistics, the National Ambulatory Medical Care Survey, the National Inpatient Sample, the Centers for Disease Control and Prevention, and the National Cancer Institute, as well as proprietary pharmaceutical databases to construct a report on the impact of gastrointestinal and liver diseases on the U.S. population. We compiled information on causes of death, hospitalization, clinic visits, cancer incidence, and mortality and infectious disease incidence from these databases, and extracted data specific to gastrointestinal diseases. Because of the high costs associated with medications used to treat gastrointestinal diseases, we also include in this year's report a special section on pharmacoepidemiology and pharmacoeconomics. RESULTS: Colorectal cancer continues to be the leading cause of GI-related death, although the data indicate a downward trend in deaths. Abdominal pain, diarrhea, vomiting, and nausea are the most common GI symptoms precipitating a visit to the physician, and GERD is the most common GI-related diagnosi...