Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

作者：C. Lucas, Hye Sun Kuehn, Fang Zhao, Julie E. Niemela, Elissa K. Deenick, Umaimainthan Palendira, Danielle T. Avery, Leen Moens, Jennifer L. Cannons, Matthew Biancalana, Jennifer Stoddard, Weiming Ouyang, David M. Frucht, V. Koneti Rao, T. Prescott Atkinson, Anahita Agharahimi, Ashleigh A. Hussey, Les Folio, Kenneth N. Olivier, Thomas A. Fleisher, Stefania Pittaluga, Steven M. Holland, Jeffrey I. Cohen, João Bosco Oliveira, Stuart G. Tangye, Pamela L. Schwartzberg, Michael J. Lenardo, Gülbû Uzel · 发表于：Nature Immunology · 年份：2013 · DOI：10.1038/ni.2771 · 被引用次数：675 · 研究领域：Immunodeficiency and Autoimmune Disorders、Ubiquitin and proteasome pathways、PI3K/AKT/mTOR signaling in cancer