The PIK3CA gene is mutated with high frequency in human breast cancers

作者：Kurtis E. Bachman, Pedram Argani, Yardena Samuels, Natalie Silliman, Janine Ptak, Steve Szabo, Hiroyuki Konishi, Bedri Karakas, Brian G. Blair, Clarence Lin, Brock A. Peters, Victor E. Velculescu, Ben Ho Park · 发表于：Cancer Biology & Therapy · 年份：2004 · DOI：10.4161/cbt.3.8.994 · 被引用次数：668 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Advanced Breast Cancer Therapies

The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been reported that somatic mutations within the PI3K subunit p110alpha (PIK3CA) are present in human colorectal and other cancers. Here we show that thirteen of fifty-three breast cancers (25%) contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain. These results demonstrate that PIK3CA is the most mutated oncogene in breast cancer and support a role for PIK3CA in epithelial carcinogenesis.