Artemis 123: development of a whole-head infant and young child MEG system

作者：Timothy P. L. Roberts, D. N. Paulson, E. C. Hirschkoff, Kevin Pratt, Anthony Mascarenas, Paul Miller, Mengali Han, J.M. Caffrey, Chuck Kincade, Bill Power, Rebecca Murray, Vivian Chow, C. Joseph Fisk, Matthew Ku, Darina Chudnovskaya, John Dell, Rachel Golembski, Peter Lam, Lisa Blaskey, Emily S. Kuschner, Luke Bloy, William Gaetz, J. Christopher Edgar · 发表于：Frontiers in Human Neuroscience · 年份：2014 · DOI：10.3389/fnhum.2014.00099 · 被引用次数：56 · 研究领域：Functional Brain Connectivity Studies、Neuroscience and Music Perception、EEG and Brain-Computer Interfaces

BACKGROUND: A major motivation in designing the new infant and child magnetoencephalography (MEG) system described in this manuscript is the premise that electrophysiological signatures (resting activity and evoked responses) may serve as biomarkers of neurodevelopmental disorders, with neuronal abnormalities in conditions such as autism spectrum disorder (ASD) potentially detectable early in development. Whole-head MEG systems are generally optimized/sized for adults. Since magnetic field produced by neuronal currents decreases as a function of distance(2) and infants and young children have smaller head sizes (and thus increased brain-to-sensor distance), whole-head adult MEG systems do not provide optimal signal-to-noise in younger individuals. This spurred development of a whole-head infant and young child MEG system - Artemis 123. METHODS: In addition to describing the design of the Artemis 123, the focus of this manuscript is the use of Artemis 123 to obtain auditory evoked neuromagnetic recordings and resting-state data in young children. Data were collected from a 14-month-old female, an 18-month-old female, and a 48-month-old male. Phantom data are also provided to show localization accuracy. RESULTS: Examination of Artemis 123 auditory data showed generalizability and reproducibility, with auditory responses observed in all participants. The auditory MEG measures were also found to be manipulable, exhibiting sensitivity to tone frequency. Furthermore, there appeared...