Interindividual Variation in Binding of Benzo[ a ]pyrene to DNA in Cultured Human Bronchi

作者：Curtis C. Harris, Herman Autrup, Robert D. Connor, Lucy A. Barrett, Elizabeth M. McDowell, Benjamin F. Trump · 发表于：Science · 年份：1976 · DOI：10.1126/science.982061 · 被引用次数：135 · 研究领域：Heme Oxygenase-1 and Carbon Monoxide、Neuroscience of respiration and sleep、Electron Spin Resonance Studies

The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.