Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimerʼs disease

作者：Joseph H. Su, Takao Satou, Aileen J. Anderson, Carl W. Cotman · 发表于：Neuroreport · 年份：1996 · DOI：10.1097/00001756-199601310-00015 · 被引用次数：97 · 研究领域：DNA and Nucleic Acid Chemistry、DNA Repair Mechanisms、RNA Interference and Gene Delivery

Cell death and neurofibrillary tangle formation are prominent features of Alzheimer's disease (AD). It has been suggested that DNA damage may reflect neuronal vulnerability. In this context, the Ced homologue Bcl-2 is able to repress a number of cell death programs. Recently we found both numerous nuclei exhibiting DNA damage within neurons in the AD brain and increases in Bcl-2 immunoreactivity. In this study, we examined the relationship between Bcl-2 expression and nuclear DNA damage or tangle formation. Nuclei exhibiting DNA damage were associated with an up-regulation of Bcl-2 expression, whereas tangle-bearing neurons were associated with a down-regulation of Bcl-2 expression.