Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.

作者：Josiah N. Wilcox, Kevin M. Smith, Lewis T. Williams, Stephen Mark Schwartz, David J. Gordon · 发表于：Journal of Clinical Investigation · 年份：1988 · DOI：10.1172/jci113671 · 被引用次数：482 · 研究领域：Atherosclerosis and Cardiovascular Diseases、Cell Adhesion Molecules Research、Galectins and Cancer Biology

Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.