High-Yielding Intramolecular Direct Arylation Reactions with Aryl Chlorides

作者：Louis‐Charles Campeau, Praew Thansandote, Keith Fagnou · 发表于：Organic Letters · 年份：2005 · DOI：10.1021/ol050501v · 被引用次数：239 · 研究领域：Catalytic Cross-Coupling Reactions、N-Heterocyclic Carbenes in Organic and Inorganic Chemistry、Catalytic C–H Functionalization Methods

[reaction: see text] An N-heterocyclic carbene palladium catalyst system is used to promote direct arylation of a broad range of aryl chlorides to form six- and five-membered ring biaryls. An influence of the halide on the palladium precatalyst on catalyst activation has been revealed, as has a beneficial effect of NHC salts that allows the turnover numbers to be increased by simple addition of imidazolium salts to the reaction mixture.