Circadian Timekeeping in Health and Disease

作者：Martin C. Moore‐Ede, Charles Andrew Czeisler, Gary S. Richardson · 发表于：New England Journal of Medicine · 年份：1983 · DOI：10.1056/nejm198308253090806 · 被引用次数：364 · 研究领域：Circadian rhythm and melatonin、Dietary Effects on Health、Spaceflight effects on biology

THE study of circadian (approximately 24-hour) rhythms has within the past decade evolved from a biologic curiosity to a science with enormous implications for clinical medicine. The concurrent maturation of circadian oscillator theory, the anatomic definition of circadian pacemakers in mammals, and the identification of a considerable number of persons with malfunctions of the circadian timing system have formed the basis of a new medical discipline.1 Circadian rhythms relate to clinical medicine in two major ways. First, circadian rhythmicity is such a pervasive element of human physiology that its recognition has required a reassessment of many clinical diagnostic and therapeutic . . .