Iron homeostasis and management of oxidative stress response in bacteria

作者：Pierre Cornélis, Qing Wei, Simon Colin Andrews, Tiffany Vinckx · 发表于：Metallomics · 年份：2011 · DOI：10.1039/c1mt00022e · 被引用次数：336 · 研究领域：Microbial Fuel Cells and Bioremediation、Cassava research and cyanide、Metal Extraction and Bioleaching

Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction. For these reasons, bacteria must tightly control the uptake and storage of iron in a manner that restricts the build-up of ROS. Therefore, it is not surprising to find that the control of iron homeostasis and responses to oxidative stress are coordinated. The mechanisms concerned with these processes, and the interactions involved, are the subject of this review. Tight control of iron uptake avoids the accumulation of toxic levels of iron which can promote ROS production, whilst mounting a strong anti-oxidative stress response is apparently necessary in the management of iron homeostasis.