Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

作者：Chi-Wing Chow, Mercedes Rincón, Julie Cavanagh, Martin Dickens, Roger J. Davis · 发表于：Science · 年份：1997 · DOI：10.1126/science.278.5343.1638 · 被引用次数：365 · 研究领域：Signaling Pathways in Disease、Heat shock proteins research、RNA Interference and Gene Delivery

The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4. In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.