Fabrication and characterization of novel nano‐ and micro‐HA/PCL composite scaffolds using a modified rapid prototyping process

作者：Su‐Jin Heo, Seung‐Eon Kim, Jie Wei, Yong‐Taek Hyun, Hui‐suk Yun, Dong‐Hwa Kim, Ji Won Shin, Jung‐Woog Shin, Jung‐Woog Shin, Jung‐Woog Shin · 发表于：Journal of Biomedical Materials Research Part A · 年份：2008 · DOI：10.1002/jbm.a.31726 · 被引用次数：133 · 研究领域：Bone Tissue Engineering Materials、Additive Manufacturing and 3D Printing Technologies、biodegradable polymer synthesis and properties

Novel three-dimensional scaffolds consisting of nano- and microsized hydroxyapatite (HA)/poly(epsilon-caprolactone) (PCL) composite were fabricated using a modified rapid-prototyping (RP) technique for bone tissue engineering applications. The size of the nano-HA ranged from 20 to 90 nm, whereas that of the micro-HA ranged from 20 to 80 microm. The scaffold macropores were well interconnected, with a porosity of 72-73% and a pore size of 500 microm. The compressive modulus of the nano-HA/PCL and micro-HA/PCL scaffolds was 3.187 +/- 0.06 and 1.345 +/- 0.05 MPa, respectively. The higher modulus of the nano-HA/PCL composite (n-HPC) was to be likely caused by a dispersion strengthening effect. The attachment and proliferation of MG-63 cells on n-HPC were better than that on the micro-HA/PCL composite (m-HPC) scaffold. The n-HPC was more hydrophilic than the m-HPC because of the greater surface area of HA exposed to the scaffold surface. This may give rise to better cell attachment and proliferation. Bioactive n-HA/PCL composite scaffold prepared using a modified RP technique has a potential application in bone tissue engineering.