Quantitative Computed Tomography Measures of Pectoralis Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease. A Cross-Sectional Study

作者：Merry‐Lynn McDonald, Alejandro A. Díaz, James C. Ross, Raúl San Jośe Estépar, Linfu Zhou, Elizabeth A. Regan, Eric Eckbo, Nina Muralidhar, Carolyn E. Come, Michael H. Cho, Craig P. Hersh, Christoph Lange, Emiel F.�M. Wouters, Richard Casaburi, Harvey O. Coxson, William MacNee, Stephen I. Rennard, David A. Lomas, Àlvar Agustí, Bartolomé R. Celli, Jennifer L. Black‐Shinn, Gregory L. Kinney, Sharon M. Lutz, John E. Hokanson, Edwin K. Silverman, George R. Washko · 发表于：Annals of the American Thoracic Society · 年份：2014 · DOI：10.1513/annalsats.201307-229oc · 被引用次数：252 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Pectus Deformity Diagnosis and Treatment、Nutrition and Health in Aging

RATIONALE: Muscle wasting in chronic obstructive pulmonary disease (COPD) is associated with a poor prognosis and is not readily assessed by measures of body mass index (BMI). BMI does not discriminate between relative proportions of adipose tissue and lean muscle and may be insensitive to early pathologic changes in body composition. Computed tomography (CT)-based assessments of the pectoralis muscles may provide insight into the clinical significance of skeletal muscles in smokers. OBJECTIVES: We hypothesized that objective assessment of the pectoralis muscle area on chest CT scans provides information that is clinically relevant and independent of BMI. METHODS: Data from the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) Study (n = 73) were used to assess the relationship between pectoralis muscle area and fat-free mass. We then used data in a subset (n = 966) of a larger cohort, the COPDGene (COPD Genetic Epidemiology) Study, to explore the relationship between pectoralis muscle area and COPD-related traits. MEASUREMENTS AND MAIN RESULTS: We first investigated the correlation between pectoralis muscle area and fat-free mass, using data from a subset of participants in the ECLIPSE Study. We then further investigated pectoralis muscle area in COPDGene Study participants and found that higher pectoralis muscle area values were associated with greater height, male sex, and younger age. On subsequent clinical correlation, compared with B...