Effect of combined therapy with phosphate and calcitonin on bone volume in osteoporosis

作者：H Rasmussen, P Bordier, Pierre J. Marie, Louis Auquier, Jean Eisinger, D Kuntz, Francine Caulin, Bruno Argémi, J Guéris, Anne‐Sophie Julien · 发表于：Metabolic Bone Disease and Related Research · 年份：1980 · DOI：10.1016/0221-8747(80)90006-5 · 被引用次数：74 · 研究领域：Bone health and osteoporosis research、Bone health and treatments、Bone Metabolism and Diseases

Twenty-six patients with postmenopausal osteoporosis were randomly divided into three treatment groups and were then treated for a period of six months with either : 1) double placebo ; II) oral placebo and parenteral calcitonin ; or III) oral phosphate and parenteral calcitonin. The study was carried out with a double blind protocol. Bone biopsies were obtained before and after the period of treatment and quantitative histomorphometry was performed on these biopsies by two independent observers. The results show that in patients in groups I and 11 there was no significant change In trabecular bone mass or In bone remodeling parameters. However, patients in group III showed a 36 percent increase in trabecular bone mass and an 85 percent increase in extent of bone formation surface without a significant Increase In either osteoclast count or extent of bone resorption surface. In treatment group III plasma immunoreactive PTH also rose significantly. Vingt-six patientes atteintes d'ostéoporose post-ménopausique ont été divisées au hasard en trois groupes traités pendant une péiods de six mois avec suit l) double placebo, soit 11) placebo oral et calcitonine parentérale, soit III) phosphate oral et calcitonine parentéralse, de manibre séquentielle. L'étude a été menée suivant un protocols on double aveugle. Des biopsies osseuses ont été prélevées avant et aprbs to periods de traitement et I'histomorphométrie réalisée per deux observateurs independents. Les résuhats montrent l'abs...