Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

作者：Christian G. Nelson, Vivian R. Albert, Harry P. Elsholtz, Leslie I.-W. Lu, Michael G. Rosenfeld · 发表于：Science · 年份：1988 · DOI：10.1126/science.2831625 · 被引用次数：527 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Adipose Tissue and Metabolism、Cancer, Hypoxia, and Metabolism

In the anterior pituitary gland, there are five phenotypically distinct cell types, including cells that produce either prolactin (lactotrophs) or growth hormone (somatotrophs). Multiple, related cis-active elements that exhibit synergistic interactions appear to be the critical determinants of the transcriptional activation of the rat prolactin and growth hormone genes. A common positive tissue-specific transcription factor, referred to as Pit-1, appears to bind to all the cell-specific elements in each gene and to be required for the activation of both the prolactin and growth hormone genes. The data suggest that, in the course of development, a single tissue-specific factor activates sets of genes that ultimately exhibit restricted cell-specific expression and define cellular phenotype.