Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms

作者：Balaraman Kalyanaraman · 发表于：Redox Biology · 年份：2013 · DOI：10.1016/j.redox.2013.01.014 · 被引用次数：505 · 研究领域：Vitamin C and Antioxidants Research、Nitric Oxide and Endothelin Effects、Coenzyme Q10 studies and effects

This article provides a succinct but limited overview of the protective and deleterious effects of reactive oxygen and nitrogen species in a clinical context. Reactive oxygen species include superoxide, hydrogen peroxide, single oxygen and lipid peroxides. Reactive nitrogen species include species derived from nitric oxide. This review gives a brief overview of the reaction chemistry of these species, the role of various enzymes involved in the generation and detoxification of these species in disease mechanisms and drug toxicity and the protective role of dietary antioxidants. I hope that the graphical review will be helpful for teaching both the first year medical and graduate students in the U.S. and abroad the fundamentals of reactive oxygen and nitrogen species in redox biology and clinical medicine.