NET POTASSIUM MOVEMENT BETWEEN RESTING MUSCLE AND PLASMA IN MAN IN THE BASAL STATE AND DURING THE NIGHT 1

作者：Reubin Andres, Gordon Cader, Peter J. Goldman, Kenneth L. Zierler · 发表于：Journal of Clinical Investigation · 年份：1957 · DOI：10.1172/jci103475 · 被引用次数：27 · 研究领域：Chemical and Physical Studies、Energy, Environment, Agriculture Analysis、Exercise and Physiological Responses

Net movement of potassium between cells and extracellular fluid has been demonstrated in a variety of experimental conditions by direct analysis of muscle, by metabolic balance techniques, and by measurement of differences in potassium con- centration in arterial blood and venous blood drain- ing muscle.It has, for example, been demon- stated that potassium leaves muscle during exer- cise, anoxia, potassium depletion, and under the influence of acidosis and of adrenal cortical hor- mones (1).The present study demonstrates that there are, in addition, diurnal fluctuations in movement of potassium between skeletal muscle and extra- cellular fluid.Net movement of potassium be- tween plasma and muscles of the forearm has been determined in human subjects by a technique which permits continuous monitoring of move- ment of potassium in relatively undisturbed muscle.Concentration of potassium is measured in arterial plasma and in venous plasma draining the deep forearm tissues.Plasma flow through the forearm is measured by the dye-dilution method (2).The product of flow, F, and the difference in arterio- venous concentration, A-V, defines Q, the net quantity of potassium entering or leaving the fore- arm tissues per unit time. METHODSIn vivo studies.Twenty-one male subjects (16 medical students and laboratory personnel and five convalescent ambulatory patients) were studied in the basal state between the hours of 10 A.M. and 1 P.M.Three medical